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Individual Overexpression Of Five Subunits Of Human Translation Initiation Factor Eif3 Promotes Malignant Transformation Of Immortal Fibroblast Cells

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 8 (2007): 5790-5800

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Transcriptional and post-transcriptional regulatory mechanisms are commonly accepted paradigms of tumorigenesis. The view is emerging that deregulation of translation contributes importantly to cancer development, a role not generally appreciated before. Eukaryotic initiation factor eIF3 contains at least thirteen non-identical subunits, ...更多

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Lili Zhang
Lili Zhang
John W B Hershey
John W B Hershey
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