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Cellular and viral DNA hypomethylation associated with induction of Epstein-Barr virus lytic cycle.

Proceedings of the National Academy of Sciences of the United States of America, no. 23 (1985): 8090-8094

Cited by: 68|Views1
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Abstract

Epstein-Barr virus (EBV) producer and nonproducer cell lines have been treated with a combination of phorbol 12-myristate 13-acetate and n-butyrate (sodium salt). These inducers caused a massive hypomethylation of the EBV producer line P3HR-1 DNA (about 30%) at the time when DNA replication was inhibited. The viral DNA in these cells is h...More

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