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Impaired binding of standard initiation factors mediates poliovirus translation attenuation.

JOURNAL OF VIROLOGY, no. 1 (2003): 115-122

Cited: 79|Views27
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Abstract

In the oral poliovirus vaccine, three attenuated virus strains generated by Albert Sabin are used. However, insufficient genetic stability of these strains causes major problems in poliovirus eradication. In infected cells, translation of the plus-strand poliovirus RNA genome is directed by the internal ribosome entry site (IRES), a cis-a...More

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