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The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication.
NATURE CELL BIOLOGY, no. 7 (2006): 717.0-U143
WOS NATURE
Abstract
Emerging evidence suggests that supernumerary centrosomes drive genome instability and oncogenesis(1-3). Human T-cell leukaemia virus type I ( HTLV-I) is etiologically associated with adult T-cell leukaemia ( ATL) 4. ATL cells are aneuploid, but the causes of aneuploidy are incompletely understood(5,6). Here, we show that centrosome ampli...More
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