Quinoline Derivative Mc1626, A Putative Gcn5 Histone Acetyltransferase (Hat) Inhibitor, Exhibits Hat-Independent Activity Against Toxoplasma Gondii
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY(2007)
摘要
We report that quinoline derivative MC1626, first described as an inhibitor of the histone acetyltransferase (HAT) GCN5, is active against the protozoan parasite Toxoplasma gondii in vitro. However, MC1626 does not inhibit Toxoplasma GCN5 HATs or reduce HAT-mediated activity; rather, this quinoline may target the plastid organelle called the apicoplast.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要