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Sphingolipid Synthesis As A Target For Antifungal Drugs - Complementation Of The Inositol Phosphorylceramide Synthase Defect In Strain Of Saccharomyces Cerevisiae By The Aur1 Gene

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 15 (1997): 9809-9817

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We have identified a Saccharomyces cerevisiae gene necessary for the step in sphingolipid synthesis in which inositol phosphate is added to ceramide to form inositol-P-ceramide a reaction catalyzed by phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase). This step should be an effective target for antifungal drugs. A k...更多

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