Sphingolipid Synthesis As A Target For Antifungal Drugs - Complementation Of The Inositol Phosphorylceramide Synthase Defect In Strain Of Saccharomyces Cerevisiae By The Aur1 Gene

We have identified a Saccharomyces cerevisiae gene necessary for the step in sphingolipid synthesis in which inositol phosphate is added to ceramide to form inositol-P-ceramide a reaction catalyzed by phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase). This step should be an effective target for antifungal drugs. A k...更多