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Functional conservation of Pax6 regulatory elements in humans and mice demonstrated with a novel transgenic reporter mouse

BMC Developmental Biology, no. 1 (2006): 21-11

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BACKGROUND: The Pax6 transcription factor is expressed during development in the eyes and in specific CNS regions, where it is essential for normal cell proliferation and differentiation. Mice lacking one or both copies of the Pax6 gene model closely humans with loss-of-function mutations in the PAX6 locus. The sequence of the Pax6/PAX6 p...更多

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