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Heparin binding induces conformational changes in Adeno-associated virus serotype 2

Journal of Structural Biology, no. 3 (2009): 146-156

被引用93|浏览15
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Adeno-associated virus serotype 2 (AAV2) uses heparan sulfate proteoglycan as a cell surface-attachment receptor. In this study the structures of AAV2 alone and complexed with heparin were determined to ∼18Å resolution using cryo-electron microscopy and three-dimensional image reconstruction. A difference map showed positive density, mode...更多

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