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Activation Kinetics of AMPA Receptor Channels Reveal the Number of Functional Agonist Binding Sites

JOURNAL OF NEUROSCIENCE, no. 1 (1998): 119-127

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academic.microsoft.com pubmed.ncbi.nlm.nih.gov

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glutamate receptorsAMPA receptorscyclothiazidehippocampusion channelsMore(1+)

Abstract

AMPA and NMDA receptor channels are closely related molecules, yet they respond to glutamate with distinct kinetics, attributable to differences in ligand binding and channel gating steps (for review,; see Edmonds et al., 1995). We used two complementary approaches to investigate the number of functional binding sites on AMPA channels on ...More

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