The Tumor Bed Effect: Increased Metastatic Dissemination From Hypoxia-Induced Up-Regulation Of Metastasis-Promoting Gene Products

CANCER RESEARCH, no. 6 (2005): 2387-2396

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Cancer patients with recurrent local disease after radiation therapy have increased probability of developing regional and distant metastases. The mechanisms behind this observation were studied in the present work by using D-12 and R-18 human melanoma xenografts growing in preirradiated beds in BALB/c-nu/nu mice as preclinical models of ...更多

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