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Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways.

MOLECULAR AND CELLULAR BIOLOGY, no. 1 (2009): 68-82

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TRAIL is an endogenous death receptor ligand also used therapeutically because of its selective proapoptotic activity in cancer cells. In the present study, we examined chromatin alterations induced by TRAIL and show that TRAIL induces a rapid activation of DNA damage response (DDR) pathways with histone H2AX, Chk2, ATM, and DNA-PK phosph...更多

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