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Inhibited Cell Growth And Protein Functional Changes From An Editing-Defective Trna Synthetase

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, no. 5 (2005): 1697-1701

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aminoacylation errors genetic code ambiguity amino acid misincorporation

Abstract

The genetic code is established in aminoacylation reactions catalyzed by aminoacyl-tRNA synthetases. Many aminoacyl-tRNA synthetases require an additional domain for editing, to correct errors made by the catalytic domain. A nonfunctional editing domain results in an ambiguous genetic code, where a single codon is not translated as a spec...More

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Jamie M. Bacher

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Valérie de Crécy-Lagard

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Paul R. Schimmel

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