Oligomerization Of Vibrio Cholerae Cytolysin Yields A Pentameric Pore And Has A Dual Specificity For Cholesterol And Sphingolipids In The Target Membrane

Vibrio cholerae cytolysin permeabilizes animal cell membranes Upon binding to the target lipid bilayer, the protein assembles into homo oligomeric pores of an as yet unknown stoichiometry Pore formation has been observed with model liposomes consisting of phosphatidylcholine and cholesterol, but the latter were much less susceptible to th...更多