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Expression of cyclooxygenase 2, microsomal prostaglandin E synthase 1, and EP receptors is increased in rat oesophageal squamous cell dysplasia and Barrett's metaplasia induced by duodenal contents reflux

GUT, no. 1.0 (2004): 27-33

Cited by: 61|Views3
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Abstract

Background and aim: It is known that bile acids can induce mucosal injury, stimulate cell proliferation, and promote tumorigenesis. A large body of genetic and biochemical evidence indicate that the biosynthetic pathway of prostaglandin E-2 ( PGE(2)) may play an important role in human and rodent tumours. Therefore, we examined the expres...More

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