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Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion

JOURNAL OF CLINICAL INVESTIGATION, no. 6 (2010): 1885-1894

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CD8(+) T cell responses to viral infection are characterized by the emergence of dominant and subdominant CTL populations. The immunodominance hierarchies of these populations are highly reproducible for any given spectrum of virus-induced peptide-MHCI complexes and are likely determined by multiple factors. Recent studies demonstrate a d...更多

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