Breast Tumor Kinase (Protein Tyrosine Kinase 6) Regulates Heregulin-Induced Activation Of Erk5 And P38 Map Kinases In Breast Cancer Cells

CANCER RESEARCH, no. 9 (2007): 4199-4209

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Total tyrosine kinase activity is often elevated in both cytosolic and membrane fractions of malignant breast tissue and correlates with a decrease in disease-free survival. Breast tumor kinase (Brk, protein tyrosine kinase 6) is a soluble tyrosine kinase that was cloned from a metastatic breast tumor and found to be overexpressed in a ma...更多

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