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Bcl-2 affects survival but not neuronal differentiation of PC12 cells.
JOURNAL OF NEUROSCIENCE, no. 10 (1993): 4422-4428
Past studies have shown that serum-free cultures of PC12 cells are a useful model system for studying the mechanisms of neuronal death after neurotrophic factor deprivation. These cultures, as well as NGF-deprived cultures of sympathetic neurons, manifest an endonuclease activity that leads to "apoptotic" internucleosomal DNA cleavage. Ov...More
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