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Neuritogenesis Induced By Thyroid Hormone-Treated Astrocytes Is Mediated By Epidermal Growth Factor/Mitogen-Activated Protein Kinase-Phosphatidylinositol 3-Kinase Pathways And Involves Modulation Of Extracellular Matrix Proteins

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 51 (2002): 49311-49318

Cited by: 81|Views8
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Abstract

Thyroid hormone (T3) plays a crucial role in several steps of cerebellar ontogenesis. By using a neuron-astrocyte coculture model, we have investigated the effects of T3-treated astrocytes on cerebellar neuronal differentiation in vitro. Neurons plated onto T3-astrocytes presented a 40-60% increase on the total neurite length and an incre...More

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