OVA1 Improves the Sensitivity of the ACOG Referral Guidelines for an Ovarian Mass

Objective: The American Congress of Obstetrics and Gynecology (ACOG) has published referral guidelines for women with a pelvic mass. The guidelines use CA-125 and are reported to be less effective in early-stage disease and premenopausal women. OVA1 is a multivariate index assay approved for the preoperative evaluation of ovarian tumors. Our objective was to evaluate the performance of the ACOG guidelines using OVA1 in place of CA-125.