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DNA binding is required for the apoptogenic action of apoptosis inducing factor.
NATURE STRUCTURAL BIOLOGY, no. 9 (2002): 680.0-684.0
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The execution of apoptosis or programmed cell death comprises both caspase-dependent and caspase-independent processes. Apoptosis inducing factor (AIF) was identified as a major player in caspase-independent cell death. It induces chromatin condensation and initial DNA cleavage via an unknown molecular mechanism. Here we report the crysta...更多
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