Synthesis Of A 2-Pyrrolidinol Metabolite Of Opc-51803, A Vasopressin V-2 Receptor Agonist

Y Kawano,J Matsubara, K Kitano, T Ohtani, K Otsubo,M Komatsu, M Uchida, F Tabusa

HETEROCYCLES（2003）

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摘要

The unstable 2-pyrrolidinol derivative (2), as a metabolite of a new vasopressin V-2 receptor agonist OPC-51803 (1), was synthesized by the cytochrome P-450 model reaction of 1 with the Fe-salen complex and iodosobenzene.

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关键词

cytochrome P-450, salen complex, aminal, benzazepine, metabolite

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