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Importance of single or blended polymer types for controlled in vitro release and plasma levels of a somatostatin analogue entrapped in PLA/PLGA microspheres

Journal of Controlled Release, no. 3 (2004): 437-448

Cited: 101|Views23

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VapreotidePLGA microspheresPolymer blendControlled releaseIVIV correlation

Abstract

The aim of the work was to develop biodegradable microspheres for controlled delivery of the somatostatin analogue vapreotide and maintenance of sustained plasma levels over 2–4 weeks after a single injection in rats. Vapreotide was microencapsulated into end-group capped and uncapped low molecular weight poly(lactide) (PLA) and poly(lact...More

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Marı́a J. Blanco-Prı́eto

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