Intracellular DNA damage by lysine-acetylene conjugates
Journal of nucleic acids, Volume 2010, 2010.
Previously, we reported the design and properties of alkyne C-lysine conjugates, a powerful and tunable family of DNA cleaving reagents. We also reported that, upon photoactivation, these molecules are capable of inducing cancer cells death. To prove that the cell death stems from DNA cleavage by the conjugates, we investigated intracellu...More
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