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Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles.

JOURNAL OF CLINICAL INVESTIGATION, no. 1 (1997): 197-203

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Several observations have suggested that the enhanced proteolysis and atrophy of skeletal muscle in various pathological states is due primarily to activation of the ubiquitin-proteasome pathway. To test this idea, we investigated whether peptide aldehyde inhibitors of the proteasome, N-acetyl-leucyl-leucyl-norleucinal (LLN), or the more ...更多

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