Mapping The Pathways For O-2 Entry Into And Exit From Myoglobin

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 7 (2001): 5177-5188

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The effects of mutagenesis on geminate and bimolecular O-2 rebinding to 90 mutants at 27 different positions were used to map pathways for ligand movement into and out of sperm whale myoglobin. By analogy to a baseball glove, the protein "catches" and then "holds" incoming ligand molecules long enough to allow bond formation with the iron...更多

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