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L-Selectin Facilitation Of Metastasis Involves Temporal Induction Of Fut7-Dependent Ligands At Sites Of Tumor Cell Arrest

CANCER RESEARCH, no. 3 (2006): 1536-1542

Cited: 180|Views32
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Abstract

Hematogenous carcinoma metastasis is supported by aggregated platelets and leukocytes, forming tumor cell emboli. Early tumor cell-platelet interactions can be mediated by P-selectin binding to tumor cell surface ligands and this process is blocked by heparin. We previously showed that L-selectin deficiency also attenuates experimental me...More

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