In situ gelling xyloglucan/alginate liquid formulation for oral sustained drug delivery to dysphagic patients.

Kunihiko Itoh,Reina Tsuruya,Tetsuya Shimoyama,Hideki Watanabe,Shozo Miyazaki,Antony D'Emanuele,David Attwood

Drug Development and Industrial Pharmacy（2010）

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摘要

Liquid formulations of xyloglucan and sodium alginate in appropriate proportions are of suitable consistency for ease of administration to dysphagic patients and form gels in situ in the rat stomach capable of sustaining the release of paracetamol over a 6-hour period.

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关键词

Alginate,dysphagia,in situ gelation,oral drug delivery,paracetamol,sustained release,xyloglucan

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