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Parathyroid Hormone-Receptor Interactions Identified Directly By Photocross-Linking And Molecular Modeling Studies

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 35 (1998): 22498-22505

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Direct mapping of the interface between parathyroid hormone (PTH) and its receptor (hPTH1-Rc) was carried out by photoaffinity scanning studies. Photoreactive analogs of PTH singularly substituted with a p-benzoyl-phenylalanine (Bpa) at each of the first six N-terminal positions have been prepared. Among these, the analog [Bpa(1),Nle(8,18...更多

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