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Ex Vivo Gene Therapy In Autologous Bone Marrow Stromal Stem Cells For Tissue-Engineered Maxillofacial Bone Regeneration

GENE THERAPY, no. 24 (2003): 2013-2019

Cited: 143|Views24
WOS NATURE

Abstract

This study examines the clinical relevance of tissue engineering integrating gene therapy and polymer science to bone regeneration. Bilateral maxillary defects (3 x 1.2 cm(2)) in 20 miniature swine were bridged with a bioresorbable internal splint. Constructs were created using ex vivo adenovirus bone morphogenetic protein (BMP)-2-mediate...More

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