4-Amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes as potent FLT-3 inhibitors

Micheal D. Gaul,Guozhang Xu,Jennifer Kirkpatrick,Heidi Ott,Christian A. Baumann

Bioorganic & Medicinal Chemistry Letters（2007）

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摘要

A series of 4-amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes has been discovered and developed as potent FLT3 tyrosine kinase inhibitors. The series exhibited potent antiproliferative activity against both a FLT3 ITD-mutated human leukemic cell line as well as a wild-type FLT3 BaF3 expressed cell line.

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关键词

FLT3 tyrosine kinase,Antiproliferative,Acute myeloid leukemia

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