Thermally-Actuated Microfluidic Systems
Journal of the Association for Laboratory Automation(2008)
摘要
A new system concept has been developed for microfluidic devices in which thermal actuation is used to achieve most or all fluid and reaction control functions (e.g., valves, pumps, mixers, separators, heaters, and coolers). Thermal actuation makes it possible to incorporate the fluid-containing components in a module that can be physically separated from the actuation elements, making the fluid-bearing module disposable. The actuation elements are embedded in a reusable module, reducing the complexity and cost of the disposable unit. The thermally-actuated valve is central to the system design, and has been well characterized. Thermal-actuation concepts for other fluid-handling functions have been developed and, in most cases, demonstrated. The approach is scalable from microchip to microtiter-plate formats. It can also be integrated into existing microchip technologies to expand functionality. Prototypes have been built and tested in combination with a DNA array for diagnostics of infectious diseases.
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关键词
thermoelectric,point of care,diagnostic,temperature control,microfluidics,pump,elastomer,peltier,pcr,sample preparation,dna chip,valve,thermal cycling,dna,biomedical,lab on a chip,fluid handling,microchip,system design,infectious disease,dna array
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