Analysis of the DNA sequence and duplication history of human chromosome 15

Michael C. Zody,Manuel Garber,Ted Sharpe,Sarah K. Young,Lee Rowen,Keith O'Neill,Charles A. Whittaker,Michael Kamal,Jean L. Chang,Christina A. Cuomo,Ken Dewar,Michael G. FitzGerald,Chinnappa D. Kodira,Anup Madan,Shizhen Qin,Xiaoping Yang, Nissa Abbasi,Amr Abouelleil,Harindra M. Arachchi,Lida Baradarani,Brian Birditt,Scott Bloom,Toby Bloom,Mark L. Borowsky, Jeremy Burke,Jonathan Butler,April Cook,Kurt DeArellano,David DeCaprio,Lester Dorris III, Monica Dors,Evan E. Eichler,Reinhard Engels, Jessica Fahey, Peter Fleetwood,Cynthia Friedman, Gary Gearin, Jennifer L. Hall,Grace Hensley, Ericka Johnson, Charlien Jones, Asha Kamat,Amardeep Kaur,Devin P. Locke,Anuradha Madan, Glen Munson,David B. Jaffe,Annie Lui, Pendexter Macdonald,Evan Mauceli, Jerome W. Naylor, Ryan Nesbitt,Robert Nicol, Sinéad B. O'Leary, Amber Ratcliffe,Steven Rounsley,Xinwei She, Katherine M. B. Sneddon, Sandra Stewart,Carrie Sougnez, Sabrina M. Stone,Kerri Topham,Dascena Vincent, Shunguang Wang,Andrew R. Zimmer,Bruce W. Birren,Leroy Hood,Eric S. Lander,Chad Nusbaum

NATURE（2006）

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摘要

First fifteen Analysis of human chromosome 15 shows it to be highly segmentally duplicated. The duplications are unusual in that they are clustered in two distinct regions, rather than distributed all along the chromosome. Recombination within the duplications at one of these regions can give rise to deletions that cause Prader–Willi and Angelman syndromes.

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genomics,marine biology,neuroscience,proteomics,natural sciences,neurobiology,climate change,cell cycle,evolution,environmental science,sequence analysis,metabolomics,dna,functional genomics,molecular biology,palaeobiology,pharmacology,earth science,genome sequence,geophysics,human genome,transcriptomics,genetics,nature,polymorphism,signal transduction,astrophysics,rna,biochemistry,structural biology,computational biology,cell signalling,dna sequence,evolutionary biology,developmental biology,medicine,quantum physics,cancer,drug discovery,biotechnology,nanotechnology,medical research,biology,systems biology,bioinformatics,ecology,immunology,materials science,physics,astronomy

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