A Chemical Screen Identifies Anisomycin As An Anoikis Sensitizer That Functions By Decreasing Flip Protein Synthesis

Malignant epithelial cells with metastatic potential resist apoptosis that normally occurs upon loss of anchorage from the extracellular matrix, a process termed "anoikis." Resistance to anoikis enables malignant cells to survive in an anchorage-independent manner, which leads to the formation of distant metastases. To understand the regu...更多