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A Chemical Screen Identifies Anisomycin As An Anoikis Sensitizer That Functions By Decreasing Flip Protein Synthesis

CANCER RESEARCH, no. 17 (2007): 8307-8315

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Malignant epithelial cells with metastatic potential resist apoptosis that normally occurs upon loss of anchorage from the extracellular matrix, a process termed "anoikis." Resistance to anoikis enables malignant cells to survive in an anchorage-independent manner, which leads to the formation of distant metastases. To understand the regu...更多

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