The Characterization of a Novel V1b Antagonist Lead Series.

Chris A. Smethurst,Jennifer A. Borthwick,Simon Gaines,Steve Watson,Andrew Green,Mark J. Schulz,George Burton,Alberto A. Buson,Roberto Arban

Bioorganic & medicinal chemistry letters（2011）

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摘要

The SAR around a V1b antagonist HTS hit 3 was explored to produce a series of thiazole sulfonamides as a lead series with selectivity over the related V1 and oxytocin receptors.

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Vasopressin,Anxiety,Depression

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