Azalide 3,6-Ketals: antibacterial activity and structure–Activity relationships of aryl and hetero aryl substituted analogues

Subas M Sakya,Peter Bertinato,Bryan Pratt,Melani Suarez-Contreras,Kristin M Lundy,Martha L Minich,Hengmiao Cheng,Carl B Ziegler,Barbara J Kamicker,Shigeru F Hayashi,Sheryl L Santoro,David M George,Camilla D Bertsche

Bioorganic & Medicinal Chemistry Letters（2003）

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摘要

Aryl and hetero aryl substituted 3,6-ketals of 15-membered azalide analogues were synthesized and were found to have potent in vitro antibacterial activity against veterinary pathogens, including Staphylococcus aureus and Pasteurella multocida.

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