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C4b-binding protein binds to necrotic cells and DNA, limiting DNA release and inhibiting complement activation

MOLECULAR IMMUNOLOGY, no. 1-2 (2006): 126-126

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After cell death, via apoptosis or necrosis, the uptake of dead cells by neighboring cells or phagocytes prevents the release of intracellular content. An array of molecules, including initiation molecules of the complement system, are involved in marking dead cells for uptake. After binding of these molecules, complement activation takes...更多

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