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Implications Of A Quasispecies Genome Structure - Effect Of Frequent, Naturally-Occurring Amino-Acid Substitutions On The Antigenicity Of Foot-And-Mouth-Disease Virus

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, no. 15 (1989): 5883-5887

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We provide evidence that the quasispecies nature (extreme genetic heterogeneity) of foot-and-mouth disease virus is relevant to the virus evading an immune response. A monoclonal antibody neutralizing the viral infectivity (clone SD6) recognizes an epitope located around a highly conserved sequence (amino acid sequence Arg-Gly-Asp-Leu-Ala...更多

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