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Chromatin remodeling of the interleukin-2 gene: Distinct alterations in the proximal versus distal enhancer regions

NUCLEIC ACIDS RESEARCH, no. 12.0 (1998): 2923-2934

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Known transcription factor-DNA interactions in the minimal enhancer of the murine interleukin-2 gene (IL-2) do not easily explain the T cell specificity of IL-2 regulation. To seek additional determinants of cell type specificity, in vivo methodologies were employed to examine chromatin structure 5' and 3' of the 300 bp IL-2 proximal prom...更多

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