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Allelic Sequence Variation Of The Hla-Dq Loci - Relationship To Serology And To Insulin-Dependent Diabetes Susceptibility

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, no. 16 (1988): 6012-6016

Cited: 109|Views23
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Abstract

Analysis of sequence variation in the polymorphic second exon of the major histocompatibility complex genes HLA-DQ alpha and -DQ beta has revealed 8 allelic variants at the alpha locus and 13 variants at the beta locus. Correlation of sequence variation with serologic typing suggests that the DQw2, DQw3, and DQ(blank) types are determined...More

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