Two Molecular Pathways Initiate Mitochondria-Dependent Dopaminergic Neurodegeneration In Experimental Parkinson'S Disease

Dysfunction of mitochondrial complex I is associated with a wide spectrum of neurodegenerative disorders, including Parkinson's disease (PD). In rodents, inhibition of complex I leads to degeneration of dopaminergic neurons of the substantia nigra pars compacta (SNpc), as seen in PD, through activation of mitochondria-dependent apoptotic ...更多