Immunological And Biochemical Correlates Of Adjunctive Dexamethasone In Vietnamese Adults With Bacterial Meningitis

Nguyen Thi Hoang Mai, Trung Vu Tuan,Marcel Wolbers,Dang Minh Hoang,Tran Vu Thieu Nga,Tran Thi Hong Chau,Ly Van Chuong,Dinh Xuan Sinh,Ho Dang Trung Nghia,Nguyen Duy Phong,Nguyen Hoan Phu,To Song Diep, Hoang Thi Thanh Hang,Nguyen Van Vinh Chau,Jeremy Farrar,Constance Schultsz,Tran Tinh Hien,Cameron P. Simmons

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2009）

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摘要

Adjunctive treatment to improve outcome from bacterial meningitis has centered on dexamethasone. Among Vietnamese patients with bacterial meningitis, cerebrospinal fluid (CSF) opening pressure and CSF: plasma glucose ratios were significantly improved and levels of CSF cytokines interleukin (IL)-6, IL-8, and IL-10 and were all statistically significantly lower after treatment in patients who were randomized to dexamethasone, compared with levels in patients who received placebo.

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