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Membrane Type 1-Matrix Metalloproteinase Is Regulated By Chemokines Monocyte-Chemoattractant Protein-1/Ccl2 And Interleukin-8/Cxcl8 In Endothelial Cells During Angiogenesis

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 2 (2005): 1292-1298

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academic.microsoft.com pubmed.ncbi.nlm.nih.gov

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Abstract

We have investigated the putative role and regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in angiogenesis induced by inflammatory factors of the chemokine family. The absence of MT1-MMP from null mice or derived mouse lung endothelial cells or the blockade of its activity with inhibitory antibodies resulted in the specif...More

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