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CNS1 Encodes an Essential p60/Sti1 Homolog in Saccharomyces cerevisiae That Suppresses Cyclophilin 40 Mutations and Interacts with Hsp90
MOLECULAR AND CELLULAR BIOLOGY, no. 12 (1998): 7344-7352
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摘要
Cyclophilins are cis-trans-peptidyl-prolyl isomerases that bind to and are inhibited by the immunosuppressant cyclosporin A (CsA), The toxic effects of CsA are mediated by the 18-kDa cyclophilin a protein. A larger cyclophilin of 40 kDa, cyclophilin 40, is a component of Hsp90-steroid receptor complexes and contains two domains, an amino-...更多
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