Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin.

NATURE GENETICS, no. 2 (2002): 205-209

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The zebrafish embryo is transparent and can tolerate absence of blood flow because its oxygen is delivered by diffusion rather than by the cardiovascular system(1). It is therefore possible to attribute cardiac failure directly to particular genes by ruling out the possibility that it is due to a secondary effect of hypoxia. We focus here...更多

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