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Cell Cycle-Dependent And Schedule-Dependent Antitumor Effects Of Sorafenib Combined With Radiation

CANCER RESEARCH, no. 19 (2007): 9443-9454

Cited: 110|Views31
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Abstract

The antineoplastic drug sorafenib (BAY 43-9006) is a multikinase inhibitor that targets the serine-threonine kinase B-Raf as well as several tyrosine kinases. Given the numerous molecular targets of sorafenib, there are several potential anticancer mechanisms of action, including induction of apoptosis, cytostasis, and antiangiogenesis. W...More

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