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Apolipoprotein B Production Reduces Lipotoxic Cardiomyopathy - Studies In Heart-Specific Lipoprotein Lipase Transgenic Mouse

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 6 (2004): 4204-4211

Cited: 94|Views22
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Abstract

Lipid accumulation is associated with cardiac dysfunction in diabetes and obesity. Transgenic mice expressing non-transferable lipoprotein lipase (LpL) with a glycosylated phosphatidyl-inositol (GPI) anchor in cardiomyocytes have dilated cardiomyopathy. However, the mechanisms responsible for lipid accumulation and cardiomyopathy are not ...More

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