Regulation Of The Assembly And Adhesion Activity Of E-Cadherin By Nectin And Afadin For The Formation Of Adherens Junctions In Madin-Darby Canine Kidney Cells

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 8 (2006): 5288-5299

Cited: 111|Views29
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Abstract

The Ca2+-independent immunoglobulin-like molecule nectin first forms cell-cell adhesion and then assembles cadherin at nectin-based cell-cell adhesion sites, resulting in the formation of adherens junctions (AJs). Afadin is a nectin- and actin filament-binding protein that connects nectin to the actin cytoskeleton. Here, we studied the ro...More

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