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Thyroid Hormone Response Elements Differentially Modulate The Interactions Of Thyroid Hormone Receptors With Two Receptor Binding Domains In The Steroid Receptor Coactivator-1

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 34 (1998): 21554-21562

Cited: 67|Views29
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Abstract

Ligand-dependent transcriptional activation by nuclear receptors is mediated by interactions with coactivators. Recently, a consensus interaction motif (LXXLL) has been identified in a number of coactivators such as steroid receptor coactivator-l (SRC-1). SRC-1 contains three such motifs in the central (nuclear receptor binding domain-1, ...More

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