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Induction Of The Nrf2-Driven Antioxidant Response Confers Neuroprotection During Mitochondrial Stress In Vivo

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 24 (2005): 22925-22936

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academic.microsoft.com pubmed.ncbi.nlm.nih.gov

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Abstract

NF-E2 related factor (Nrf2) controls a pleiotropic cellular defense, where multiple antioxidant/detoxification pathways are up-regulated in unison. Although small molecule inducers of Nrf2 activity have been reported to protect neurons in vitro, whether similar pathways can be accessed in vivo is not known. We have investigated whether in...More

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