Protein Phosphatase-1 Dephosphorylates The C-Terminal Domain Of Rna Polymerase-Ii

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 43 (2002): 40442-40448

Cited: 68|Views28
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Abstract

Transcription by RNA polymerase-II (RNAPII) is controlled by multisite phosphorylation of the heptapeptide repeats in the C-terminal domain (CTD) of the largest subunit. Phosphorylation of CTD is mediated by the cyclin-dependent protein kinases Cdk7 and Cdk9, whereas protein serine/threonine phosphatase FCP1 dephosphorylates CTD. We have ...More

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